Langzeit-Auswirkungen auf die Lunge
Chemical predictors of wheeze (01.01.02)
Hoppin JA, Umbach DM, London SJ, Alavanja MC, and Sandler DP, Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study, American Journal of Respiratory and Critical Care Medicine 165(5), 683-689, 2002
In a study of over 20’000 certified pesticide applicators in Iowa and North Carolina, the as-sociation between wheeze (whistling in the chest) and pesticide use was examined. It was found that applicators who used paraquat had elevated odds ratios (OR) for wheeze: ‘For paraquat, a chemical not associated with animal exposure, the OR for wheeze among nonasthmatics was 3.3 (95% confidence interval [CI] = 1.4, 7.6)’. The adjusted OR for wheeze among farmers who used paraquat was 1.27 (95% CI = 1.04, 1.56; p < 0.01). The authors pointed out: ‘Paraquat exposure at high doses causes pulmonary fibrosis in hu-mans and animals independent of exposure route (27). A variety of respiratory effects have been observed among occupationally exposed subjects. (...) Among our subjects, paraquat was significantly associated with wheeze in a dose-dependent fashion. Although the mechanism of action of paraquat for less severe respiratory symptoms, such as cough and wheeze, is not known, paraquat is a known skin irritant and may also irritate the mucosal surface of the lung (21)’.
References:
(21) Popendorf W, Donham KJ, Easton DN, and Silk J, A synopsis of agricultural respiratory hazards, Ameri-can Industrial Hygiene Association Journal 46, 154-161, 1985, [Medline]
(27) Honore P, Hantson P, Fauville JP, Peeters A, and Manieu P, Paraquat poisoning: “State of the art”, Acta Clinica Belgica 49, 220-228, 1994, [Medline]
Document
In a study of over 20’000 certified pesticide applicators in Iowa and North Carolina, the as-sociation between wheeze (whistling in the chest) and pesticide use was examined. It was found that applicators who used paraquat had elevated odds ratios (OR) for wheeze: ‘For paraquat, a chemical not associated with animal exposure, the OR for wheeze among nonasthmatics was 3.3 (95% confidence interval [CI] = 1.4, 7.6)’. The adjusted OR for wheeze among farmers who used paraquat was 1.27 (95% CI = 1.04, 1.56; p < 0.01). The authors pointed out: ‘Paraquat exposure at high doses causes pulmonary fibrosis in hu-mans and animals independent of exposure route (27). A variety of respiratory effects have been observed among occupationally exposed subjects. (...) Among our subjects, paraquat was significantly associated with wheeze in a dose-dependent fashion. Although the mechanism of action of paraquat for less severe respiratory symptoms, such as cough and wheeze, is not known, paraquat is a known skin irritant and may also irritate the mucosal surface of the lung (21)’.
References:
(21) Popendorf W, Donham KJ, Easton DN, and Silk J, A synopsis of agricultural respiratory hazards, Ameri-can Industrial Hygiene Association Journal 46, 154-161, 1985, [Medline]
(27) Honore P, Hantson P, Fauville JP, Peeters A, and Manieu P, Paraquat poisoning: “State of the art”, Acta Clinica Belgica 49, 220-228, 1994, [Medline]
Document
